All Publications

Investigators & Publications

Each year, GRIP awards 8-10 recipients a grant for research. Several grant investigators have published over the years. Please find them highlighted below. Additionally, most abstracts can be located on Pub Med.

2010 2009 2008 2007 2006 2005

2004 & Before

2010 - Cycle 9

Humphreys, Benjamin

INSTITUTE: Harvard Medical School, MA, USA

PROPOSAL NAME:

Translational Profiling of Vasculature in Chronic Kidney Disease

Li, Yan Chun

INSTITUTE: University of Chicago, IL, USA

PROPOSAL NAME:

Epigenetic Regulation Glomerulosclerosis in Diabetic Nephropathy

Moe, Orson

INSTITUTE: UT Southwestern Medical Center, USA

PROPOSAL NAME:

Epigenetic Regulation of Erythropoietin Receptor in the Kidney by Natural Antisense Transcript

Mrug, Michal

INSTITUTE: University of Alabama, USA

PROPOSAL NAME:

Unmasking epigenetic profiles of renal cystogenesis

Pontoglio, Marco

INSTITUTE: INSERM, Paris, France

PROPOSAL NAME:

HNF1beta/MODY5 and the epigenetic postmitotic gene expression reprogramming

Vanden Heuvel, Gregory

INSTITUTE: University of Kansas Medical Center, USA

PROPOSAL NAME:

Expression of p27 in polycystic kidney disease

Wheeler, David

INSTITUTE: UCL Medical School, London, UK

PROPOSAL NAME:

P2X7 purinoreceptor: A novel target for ameliorating vascular calcification

Zeisberg, Michael

INSTITUTE: Harvard Medical School, MA, USA

PROPOSAL NAME:

Mechanisms of Hypermethylation in Progression of Chronic Kidney Disease

2009 - Cycle 8

Duffield, Jeremy

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

The role of FCγ receptor ligation by pentraxins, serum Amyloid P and C Reactive Protein in renal fibrosis

Huang, Chou-Long

INSTITUTE: UT Southwestern Medical Center, USA

PROPOSAL NAME:

Klotho protection of glomerular proteinuria via TRPC6

Miller, Barbara

INSTITUTE: Penn State University, USA

PROPOSAL NAME:

TRPM2 in acute renal injury

Nijenhuis, Tom

INSTITUTE: Radboud University Nijmegen, Netherlands

PROPOSAL NAME:

Regulation of TRPC6 expression and activity in podocytes by RAAS, glucose and vitamin D

Reiser, Jochen

INSTITUTE: University of Miami, USA

PROPOSAL NAME:

TRPC6 signals affecting the podocyte cytoskeleton during proteinuria-chances for intervention

Robson, Michael

INSTITUTE: King's College London, UK

PROPOSAL NAME:

The role of Toll-like receptor 2 and 4 in antineutrophil cytosplamic antibody-associated vasculitis

White, Kenneth

INSTITUTE: Indiana University School of Medicine, USA

PROPOSAL NAME:

FGF23-FGFR interactions to maintain phosphate balance in CKD

PUBLICATION(s):

Farrow EG and White KE. Recent advances in renal phosphate handling. Invited review. Nature Reviews Nephrology. 2010 Apr;6(4):207-17

Farrow E, Summers L, Schiavi S, et al. Altered Renal FGF23-Mediated Activity Involving MAPK and Wnt: Effects of the Hyp Mutation. J Endocrinol. 2010; Jul 30.

Zheng, Feng

INSTITUTE: Mount Sinai School of Medicine, NY, USA

PROPOSAL NAME:

AGE mediated TLR4 activation and kidney aging

2008 - Cycle 7

Badano, Jose

INSTITUTE: Institut Pasteur de Montevideo, Uruguay

PROPOSAL NAME:

The role of MGC1203, a second site modifier of Bardet-Biedl syndrome, in cell fate decisions

PUBLICATION(s):

Cardenas-Rodriguez M and Badano J. Ciliary Biology: Understanding the Cellular and Genetic Basis of Human Ciliopathies. American Journal of Medical Genetics Part C (Seminars in Medical Genetics). 2009; 151C:263–280

Benigni, Ariela

INSTITUTE: Mario Negri Institute, Bergamo, Italy

PROPOSAL NAME:

Mesenchymal stem cell-derived exosomes reprogram damaged renal tubular cells by horizontal transfer of mRNA, microRNA and protein delivery

Bou-Gharios, George

INSTITUTE: Imperial College London, UK

PROPOSAL NAME:

Stem cell mediated renal repair in an Alport syndrome mouse model

Feng, Jerry (Jian)

INSTITUTE: Texas A&M HSC, Baylor College, USA

PROPOSAL NAME:

Disturbance of phosphate homeostasis changes osteocyte morphology and function

PUBLICATION(s):

Lu Y, Yuan B, Qin C, et al. The biological function of DMP1 in osteocyte maturation is mediated by its 57 kDa C-terminal fragment. Journal of Bone and Mineral Research. 2010 Aug 23.

Lu Y, Feng JQ. FGF23 in skeletal modeling and remodeling. Curr Osteoporos Rep. 2011 Jun;9(2):103-8.

Zhang R, Lu Y, Ye L, et al. Unique Roles of Phosphorus in Endochondral Bone Formation and Osteocyte Maturation. Bone Miner Res. 2011 May;26(5):1047-56. doi: 10.1002/jbmr.294.

Lu Y, Yuan B, Qin C, et al. The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res. 2011 Feb;26(2):331-40. doi: 10.1002/jbmr.226.

Kaplan, David

INSTITUTE: Tufts University, MA, USA

PROPOSAL NAME:

In vitro 3D tissue model for kidney disease responses

Kuro-o, Makoto

INSTITUTE: UT Southwestern Medical Center, USA

PROPOSAL NAME:

Effects of Klotho ectodomain shedding on phosphate metabolism

Salama, Alan

INSTITUTE: Imperial College London, UK

PROPOSAL NAME:

Investigating leukocyte chemotaxis in the pathogenesis of ANCA associated vasculitis and glomerulonephritis

Shah, Jagesh

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

Cilium-based signaling during tubulogenesis and cystogenesis

Smeets, Bart

INSTITUTE: University Hospital Aachen, Germany

PROPOSAL NAME:

Chemokine receptor CXCR4 and CXCR7 signaling plays a crucial role in glomerular regeneration and development of proliferative glomerular lesions

Stubbs, Jason

INSTITUTE: University of Kansas Medical Center, USA

PROPOSAL NAME:

Elucidating the role of FGF23 in disordered mineral metabolism in CKD using mouse genetic approaches

2007 - Cycle 6

Dwyer, Karen

INSTITUTE: St. Vincent's Health, Melbourne, Australia

PROPOSAL NAME:

CD39 protects against renal ischemia-reperfusion injury through the inhibition of NKT cells

PUBLICATION(s):

Lu B, Rajakumar V, Robson S, et al. The Impact of Purinergic Singnaling on Renal Ischemia-Reperfusion Injury. Transplantation. 2008;86: 1707-1712.

Hughes, Jeremy

INSTITUTE: University of Edinburgh, UK

PROPOSAL NAME:

Macrophage trafficking to and from the inflamed tubulointerstitium

Humphreys, Benjamin

INSTITUTE: Harvard Medical School, MA, USA

PROPOSAL NAME:

Genetic tracking of adult kidney progenitors in renal repair

PUBLICATION(s):

Humphreys B, Valerius M, Kobayashi A, et al. Intrinsic Epithelial Cells Repair the Kidney after Injury. Cell Stem Cell. 2008; 2, 284-291.

Song J, Czerniak S, Wang T, et al. Characterization and Fate of Telomerase-expressing Epithelia during Kidney Repair. J Am Soc Nephrol. 2011 Oct 21.

Kitching, Richard

INSTITUTE: Monash Medical Centre, Australia

PROPOSAL NAME:

Mechanisms of leukocyte activation and adherence in glomeruli in ANCA-associated glomerulonephritis in vivo

PUBLICATION(s):

Kuligowski M, Kwan R, Lo C, et al. Antimyeloperoxidase antibodies rapidly induce {alpha}4-integrin-dependent glomerular neutrophil adhesion. Blood. 2009;113: 6485-6494.

Kumar, Rajiv

INSTITUTE: Mayo Clinic, NY, USA

PROPOSAL NAME:

Identification of novel intestinal factors that rapidly alter phosphate transport

Moe, Sharon

INSTITUTE: Indiana University School of Medicine, USA

PROPOSAL NAME:

The role of Vitamin D in immune function in patients with CKD Stages 3 & 4

Nikolic-Paterson, David

INSTITUTE: Monash Medical Centre, Australia

PROPOSAL NAME:

Regulation of macrophage and T cell mediated renal injury via indoleamine 2,3-dioxygenase

Okusa, Mark

INSTITUTE: University of Virginia, USA

PROPOSAL NAME:

Kidney resident dendritic cells activate the IL-12/IFN-γ and IL-23/IL-17 axis initiating early renal IRI

Rabb, Hamid

INSTITUTE: Johns Hopkins University, MD, USA

PROPOSAL NAME:

Identification of inducible peptides that modulate leukocyte adhesion and inflammation during ischemic acute kidney injury

van Zonneveld, Anton-Jan

INSTITUTE: Leiden Univ Medical Ctr, The Netherlands

PROPOSAL NAME:

Exploring the role of microRNAs in renal endothelial regeneration

PUBLICATION(s):

van Solingen C, Seghers L, Bijkerk R, et al. Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J. Cell. Mol. Med. 2009;Vol 13, No 2, pp. 1-9.

2006 - Cycle 5

Alpers, Charles

INSTITUTE: University of Washington, Seattle, USA

PROPOSAL NAME:

Pathogenicity of foam cells in chronic renal disease

Duffield, Jeremy

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

Understanding the mechanisms of macrophage mediated progressive kidney disease

PUBLICATION(s):

Lin S, Kisseleva T, Brenner D, et al. Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney. The American Journal of Pathology., 2008;Vol. 173, No. 6.

Lin S, Castano A, Nowlin B, et al. Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations. The Journal of Immunology. 2009; Nov 15;183(10):6733-43.

Castaño A, Lin S, Surowy T, et al. Serum Amyloid P Inhibits Fibrosis Through FcgR-Dependent Monocyte-Macrophage Regulation in Vivo. Science Translational Medicine., 2009; 4 November Vol 1 Issue 5 5ra13.

Lin S, Li B, Rao S, et al. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci USA. 2010 Mar 2;107(9):4194-9.

Gross, ML & Melk, A

INSTITUTE: University of Heidelberg, Germany

PROPOSAL NAME:

The role of cellular senescence in accelerated atherogenesis of renal disease - human and experimental studies

Harris, Raymond

INSTITUTE: Vanderbilt University Medical Ctr, TN USA

PROPOSAL NAME:

Role of endothelial dysfunction due to eNOS deficiency in diabetic nephropathy

Hughey, Rebecca

INSTITUTE: University of Pittsburgh, PA USA

PROPOSAL NAME:

The role of MUC1 in EGF receptor apical expression

PUBLICATION(s):

Mattila P, Kinlough C, Bruns J, et al. MUC1 traverses apical recycling endosomes along the biosynthetic pathway in polarized MDCK cells. Biol. Chem. 2009; Jul 390(7):551-6.

Poland P, Rondanino C, Kinlough CL, et all. Identification and characterization of endogenous galectins expressed in Madin Darby canine kidney cells. J. Biol. Chem.. 2011 Feb 25;286(8):6780-90. Epub 2010 Dec 2.

Kelley, Vicki

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

The PD-1 negative regulatory pathway in macrophage mediated renal inflammation

PUBLICATION(s):

Menke J, Lucas J, Zeller G, et al. Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles The Journal of Immunology. 2007;0022-1767/07

Lucas J, Menke J, Rabacal W, et al. Programmed Death Ligand 1 Regulates a Critical Checkpoint for Autoimmune Myocarditis and Pneumonitis in MRL Mice. The Journal of Immunology. 2008;0022-1767/08

Levine, Jerrold

INSTITUTE: University of Illinois at Chicago, USA

PROPOSAL NAME:

The role of the default pathway in recovery from acute renal injury

PUBLICATION(s):

Iglesias J, DePalma L, Hom D, et al. Predictors of mortality in adult patients with congestive heart failure receiving nesiritide—Retrospective analysis showing a potential adverse interaction between neseritide and acute renal dysfunction. Nephrol Dial Transplant., 2008;23:144-153.

Patel V, Lee D, Longacre-Antoni A, et. al. Apoptotic and necrotic cells as sentinels of local tissue stress and inflammation: Response pathways initiated in nearby viable cells. Autoimmunity. 2009; 42(4): 317–321

Antoni A, Graham L, Rauch J, et al. Altered cell–cell and cell–matrix interactions in the development of systemic autoimmunity. Autoimmunity. 2009; 42(4): 278–281

Lieberthal W and Levine J. The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease. J Am Soc Nephrol. 2009; 20: 2493–2502

Dieude M, Gillis M, Theoret J, et al. Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis. Journal of Thrombosis and Haemostasis. 2009;7: 710–719.

Tolomeo T, Rico De Souza A, Roter E, et al. T cells demonstrate a Th1-biased response to native b2-glycoprotein I in a murine model of anti-phospholipid antibody induction. Autoimmunity 2009; 42(4): 292–295

Patel V, Lee D, Feng L, et al. Recognition of Apoptotic Cells by Epithelial Cells. The Journal of Biological Chemistry. 2010;Vol. 285, NO. 3, pp. 1829-1840.

Ma, Li-Jun

INSTITUTE: Vanderbilt University Medical Ctr, TN USA

PROPOSAL NAME:

Perlecan heparan sulfate modulation of podocytes and endothelial cells in diabetic nephropathy

Molema, Grietje

INSTITUTE: UMC Groningen, The Netherlands

PROPOSAL NAME:

Re(n)ality: Unmasking the true identities of the vascular endothelial cells that control renal diseases

Morigi, Marina

INSTITUTE: Mario Negri Institute, Bergamo, Italy

PROPOSAL NAME:

Role of complement in Shiga toxin-induced microvascular thrombosis: In vitro and in vivo models of Hemolytic Uremic Syndrome

2005 - Cycle 4

Antignac, C. & Esquivel, E.

INSTITUTE: Hospital Necker, Paris, France

PROPOSAL NAME:

The role of podocin in vascular development and remodeling during the progression of nephrotic syndrome

PUBLICATION(s):

Ratelade J, Lavin TA, Muda AO, et al. Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome. J Am Soc Nephrol. 2008 Aug;19(8):1491-9.

Dockrell, M. & Colville-Nash, P.

INSTITUTE: Thames Institute, Surrey, UK

PROPOSAL NAME:

The role of Id2 in TGF-β and BMP-7 signalling in the proximal tubule and its role in EMT

Féraille, Eric

INSTITUTE: University Hospital Geneva, Switzerland

PROPOSAL NAME:

Stimulation of renal sodium transport as a potential promoter of inflammation and fibrosis through activation of NK-ĸB

PUBLICATION(s):

Leroy V, De Seigneux S, Agassiz V, et al. Aldosterone Activates NF-kB in the Collecting Duct. J Am Soc Nephrol. 2009;20:131-144.

Kirby, John

INSTITUTE: University of Newcastle, UK

PROPOSAL NAME:

Chronic renal allograft nephropathy: do TGF-β expressing 'regulatory' T cells induce tubular epithelial to mesenchymal cell transition?

Kon, Valentina

INSTITUTE: Vanderbilt University Medical Ctr, TN USA

PROPOSAL NAME:

The role of angiotensin II in renal dysfunction-acceleration of atherosclerosis

Pollak, Martin

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

Identification of the genetic basis of FSGS in African-Americans using admixture mapping

Quaggin, Susan

INSTITUTE: Mount Sinai, Toronto, ON

PROPOSAL NAME:

The role of the VHL-HIF pathway in podocyte biology

Ronco, Pierre

INSTITUTE: Tenon Hospital, Paris, France

PROPOSAL NAME:

Molecular pathomechanisms of renal diseases induced by allo-immunization: Identification of pathogenic antigens and epitopes and development of antigen-specific therapy via nasal tolerance

PUBLICATION(s):

Ronco P, Debiec H. Molecular dissection of target antigens and nephritogenic antibodies in membranous nephropathy; towards epitope-driven therapies. J Am Soc Nephrol 2006, 17(7):1772-74.

Ronco P, Debiec H. New insights into membranous glomerulonephritis. Curr Opin Nephrol Hypertens 2006, 15(3): 258-63.

Debiec H, Ronco M. Fetomaternal alloimmunization with antenatal glomerulopathies. Ann NY Acad Sci, 2007, 1110:559-66.

Ronco P, Debiec H. Podocyte Antigens and Glomerular Disease Nephron Exp Nephrol. 2007, 107:41-46.

Ronco P, Debiec H. Target antigens and nephritogenic antibodies in membranous nephropathy : of rats and men Seminars in Immunopathol. 2007, 29:45-58.

Ronco P, Debiec H. Target antigens and nephritogenic antibodies in membranous nephropathy. Arch Med Sci, 2009, 5 : S442-S450.

Thameem, Farook

INSTITUTE: University of Texas San Antonio, USA

PROPOSAL NAME:

Genetics of diabetic kidney disease

Zandi-Nejad, Kambiz

INSTITUTE: Brigham & Women's Hosp, Boston, MA USA

PROPOSAL NAME:

The role of novel anion transporters SLC5A8 and SLC5A12 in renal urate transport

2004 - Cycle 3

Bluyssen, H & Braam, GB

INSTITUTE: UMC Utrecht, The Netherlands

PROPOSAL NAME:

Chronic renal failure-induced dysbalance of JAK/STAT signaling differentially affects pro- and anti-inflammatory signals and accelerates atherosclerosis

Bradley, John

INSTITUTE: Addenbrooke's Hospital, UK

PROPOSAL NAME:

Death receptor-3 in renal inflammation and injury

PUBLICATION(s):

Al-Lamki R, Wang J, Tolkovsky A, et al. TL1A Both Promotes and Protects from Renal Inflammation and Injury. J Am Soc Nephrol. 2008;19: 953-960.

Karl, Michael

INSTITUTE: Vascular Biology Institute, Miami FL USA

PROPOSAL NAME:

Preventing the development and progression of diabetic glomerulosclerosis by inhibition of mineralocorticoid receptor action

Noris, Marina

INSTITUTE: Mario Negri Institute, Bergamo, Italy

PROPOSAL NAME:

Donor engineered dendritic cells to generate tolerogenic regulatory T cells for renal transplantation

PUBLICATION(s):

Tomasoni S, Aiello S, Cassis L, et al. Dendritic cells genetically engineered with adenoviral vector encoding dnIKK2 induce the formation of potent CD4+ T-regulatory cells. Transplantation 2005;79:1056-1061.

Aiello S, Cassis P, Cassis L, et al. DnIKK2-transfected dendritic cells induce a novel population of inducile nitric oxide synthase-expressing CD+ CD25- cells with tolerogenic properties. Transplantation 2007;83:474-484.

Pacheco-Silva, Alvaro

INSTITUTE: Federal University São Paulo, Brazil

PROPOSAL NAME:

Protective genes expression and its modulation by immunosuppressive drugs in kidney transplant recipients

Phillips, Carrie

INSTITUTE: Indiana University School of Medicine, USA

PROPOSAL NAME:

Epithelial proteins contributing to infantile nephronophthisis

Smith, Kenneth GC

INSTITUTE: Cambridge Institute, UK

PROPOSAL NAME:

Gene expression profiling to target immunosuppressive therapy in lupus nephritis

Williams, Julie

INSTITUTE: University of Birmingham, UK

PROPOSAL NAME:

Mechanisms of induction of disrupted neutrophil function after binding of antineutrophil cytoplasm antibodies to proteinase 3 and co-receptors

PUBLICATION(s):

Williams J and Savage, C. Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. J Am Soc Nephrol. 2005; Jan 16(1):90-6.

Williams J, Pettitt T, Powell W, et al. Antineutrophil Cytoplasm Antibody-Stimulated Neutrophil Adhesion Depends on Diacylglycerol Kinase-Catalyzed Phosphatidic Acid Formation. J Am Soc Nephrol. 2007;18: 1112-1120.

Wong, Wilson

INSTITUTE: Guy's Hospital, London, UK

PROPOSAL NAME:

Passenger dendritic leukocytes in tolerance and rejection

PUBLICATION(s):

Brown K, Moxham V, Karegli J, et al. Ultra-Localization of Foxp3 T Cells within Renal Allografts Shows Infiltration of Tubules Mimicking Rejection. The American Journal of Pathology. 2007:171; 1915-1922.

Brown K and Wong W. Diagnostic Value of Regulatory T Cells: A New Facet of a Much Studied Cell Population. Transplantation. 2008;86:Transplantation. 2008 Dec 15;86(11):1485-91

Brown K, Sacks S, and Wong W. Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation. The FASEB Journal. 2008; Vol. 22.

Brown K and Wong W. Monitoring Regulatory T-Cells after Transplantation: Is It Useful. Trends in Transplant. 2009;3:119-28.

2003 - Cycle 2

Amann, Kerstin Ute

INSTITUTE: University Erlangen-Nürnberg, Germany

PROPOSAL NAME:

Pathogenesis and morphology of atherosclerosis in renal disease

Fontés, Michel

INSTITUTE: IPHM, Marseilles, France

PROPOSAL NAME:

Preclinical models of ADPKD: Exploration and new therapeutic targets

Jaisser, Frédéric

INSTITUTE: Inserm Avenir Collège de France

PROPOSAL NAME:

Unraveling the pathophysiological role of aldosterone in kidney diseases: Molecular and functional studies in conditional transgenic animals

Jonsson, Kenneth

INSTITUTE: Uppsala University, Sweden

PROPOSAL NAME:

FGF-23 and sFRP-4--new phosphate regulating hormones?

PUBLICATION(s):

Marsell R, Krajisnik T, Goransson H, et al. Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23. Nephrol Dial Transplant. 2008 Mar;23(3):827-33.

Kronenberg, Florian

INSTITUTE: Inst Med Biol & Human Genetics, Austria

PROPOSAL NAME:

Genetic influence on HDL cholesterol and triglyceride concentrations in hemodialysis patients and its association with atheroscerotic complications

Morigi, Marina

INSTITUTE: Mario Negri Institute, Bergamo, Italy

PROPOSAL NAME:

Role of complement in tubulointerstitial injury of proteinuric nephropathy

PUBLICATION(s):

Buelli S, Abbate M, Morigi M, et al. Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells. Kidney International. 75:1050-1059. 2009.

O'Neill, W. Charles

INSTITUTE: Emory University, Atlanta, GA USA

PROPOSAL NAME:

Role of pyrophosphate in the vascular calcification of renal failure

PUBLICATION(s):

Lomashvili K, Cobbs S, Hennigar R, et al. Phosphate-Induced Vascular Calcification: Role of Pyrophosphate and Osteopontin. J Am Soc Nephrol. 2004;15: 1392–1401.

Lomashvili K, Khawandi W, and O’Neill WC. Reduced Plasma Pyrophosphate Levels in Hemodialysis Patients. the American Society of Nephrology. 2005;1046-6673/1608-2495.

Lomashvili K, Garg P and WC O’Neill. Chemical and hormonal determinants of vascular calcification in vitro. Kidney International. 2006;69, 1464–1470.

O'Neill WC. The fallacy of calcium-phosphorus product. Kidney International. 2007;72, 792–796;

Lomashvili K, Garg P, Narisawa S, et al. Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: Potential mechanism for uremic vascular calcification. Kidney International. 2008; doi:10.1038/ki.2008.26.

O'Neill WC. Treatment of vascular calcification. Kidney International. 2008;74, 1376–1378.

Lomashvili K, Monier-Faugere M, Wang X, et al. Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure. Kidney International. 2009;75, 617-625.

Sandberg, Kathryn

INSTITUTE: Georgetown University, Wash DC USA

PROPOSAL NAME:

Investigations into gonadal hormone regulation of progressive renal disease

PUBLICATION(s):

Ji H, Zheng W, Menini S, et al. Female protection in progressive renal disease is associated with estradiol attenuation of superoxide production. Gend Med. 2007;Mar;4(1):56-71.

Ji H, Pesce C, Zheng W, et al. Sex differences in renal injury and nitric oxide production in renal wrap hypertension. Am J Physiol Heart Circ Physiol. 2005;288: H43–H47, 2005.

Zheng, Feng

INSTITUTE: Mount Sinai School of Medicine, NY, USA

PROPOSAL NAME:

Mesangial cell progenitor and aging glomerulosclerosis

2002 - Cycle 1

Alpers, Charles

INSTITUTE: University of Washington, Seattle, USA

PROPOSAL NAME:

Characterization in inflammatory responses in membranoproliferative (cryoglobulinemic) glomerulonephritis

PUBLICATION(s):

Muhlfeld A, Segerer S, Hudkins K, et al. Deletion of the Fc Receptor IIb in Thymic Stromal Lymphopoietin Transgenic Mice Aggravates Membranoproliferative Glomerulonephritis. American Journal of Pathology. 2003;Vol. 163 No. 3.

Taneda S, Hudkins K, Muhlfeld A, et al. Protease Nexin-1, tPA, and PAI-1 are Upregulated in Cryoglobulinemic Membranoproliferative Glomerulonephritis. J Am Soc Nephrol. 2008;19: 243–251.

Argilés, Àngel

INSTITUTE: Institut de Genetique Humaine, France

PROPOSAL NAME:

Transcriptome based characterisation of the molecular mechanisms involved in the renal cell response to ischemia. A central feature in acute renal failure and in renal transplantation

Benigni, Ariela

INSTITUTE: Mario Negri Institute, Bergamo, Italy

PROPOSAL NAME:

Gene delivery by 2nd generation adenovirus or adeno associated virus to donor kidney to prolong survival and induce donor-specific tolerance in a rat renal allograft model

PUBLICATION(s):

Benigni A, Tomasoni S, Turka, L, et al. Adeno-associated virus-mediated CTLA4Ig gene transfer protects MHC-mismatched renal allografts from chronic rejection. J Am Soc Nephrol. 2006;17:1665-1672.

Guan, Youfei

INSTITUTE: Vanderbilt University Medical Ctr, TN USA

PROPOSAL NAME:

Role of peroxisome proliferator-activated receptor y(PPARy) in diabetic nephropathy

Guebre-Egziabher, Fitsum

INSTITUTE: Hopital Edouard Herriot, Lyon, France

PROPOSAL NAME:

Anti-inflammatory effects of N-3 fatty acids in chronic renal failure patients

Lan, Hui Yao

INSTITUTE: Baylor College of Medicine, TX USA

PROPOSAL NAME:

Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7

Mayer, Gert

INSTITUTE: Universität Innsbruck, Austria

PROPOSAL NAME:

Telomere shortening as a determinant for allograft function in human renal transplantation

PUBLICATION(s):

Koppelstaetter C, Schratzberger G, Preco P, et al. Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell. 2008;Aug 7(4):491-7.

Pontoglio, Marco

INSTITUTE: Institut Pasteur, Paris, France

PROPOSAL NAME:

Identifying HNF1B target genes in renal dysplasia

PUBLICATION(s):

Gresh L, Fischer E, Reimann A, et al. A transcriptional network in polycystic kidney disease. The EMBO Journal. 2004;23, 1657–1668.

Fischer E, Legue E, Doyen A, et al. Defective planar cell polarity in polycystic kidney disease. Nature Genetics. 2006;Vol 38, No. 1.

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